Brian Barry-Murphy's team will welcome the Serbian club to the Joie Stadium for a 15:00 (UK) kick-off on Tuesday.
City are looking to win the prestigious competition for the first time, with our previous best finish coming as semi-finalists in 2017/18.
Our 2022/23 run came to an end in the Round of 16 against Croatia's Hajduk Split, who proved to be eventual finalists.
Domestically, we have lifted the Premier League 2 in each of the last three seasons - the first time that has ever been achieved.
With a new, younger squad for 2023/24, we have started this league campaign with one win, one draw and two defeats in our first four games.
The match is available to watch on CITY+, with coverage starting around 14:45 (UK).
Following the full-time whistle, a detailed match report, highlights and a full-match replay will be available on mancity.com and our official app alongside reaction from Barry-Murphy and a member of his squad.
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