Brian Barry-Murphy's side travel to Germany on Wednesday 4 October, with kick-off scheduled for 13:00 (UK).
City's European campaign began in impressive fashion, with a convincing 5-2 triumph over Red Star Belgrade at the Joie Stadium.
Our best finish in the competition came in 2017/18, when we reached the semi-finals, with last year's attempt ending at the Round of 16 stage.
You can watch Brian Barry-Murphy's side, the current Premier League 2 champions, in action on CITY+, with our coverage getting under way from around 12:45.
Following the full-time whistle, a detailed match report, highlights and a full-match replay will be available on mancity.com and our official app alongside reaction from Barry-Murphy and a member of his squad.
CITY+ is available via an annual subscription of £34.99 a year, saving you £24 on our monthly offering.
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Official Cityzens and Season Ticket Members can subscribe annually for £30 a year, a saving of £29.