Who will play a key role?
Lorenzo Gonzalez v Akinwale Odimayo
City's Swiss youth international has 13 goals in 19 appearances in his first season in English football - a stellar return from the 17-year-old.
His powerful running and eye for goal from any angle have played a crucial role in Gonzalez's excellent form.
He'll be up against a dominant and composed presence in Akinwale Odimayo on Wednesday but should Gonzalez look to run the channels for the Blues it's likely to be a very close foot race.
View highlights of the recent victory over Chelsea below...
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Tyreke Wilson v Joel Rollinson
Australian-raised Rollinson is a pacey, direct winger and as a second-year scholar will be looking to use his experience to spur his side on.
Ireland U19 international full-back Wilson isn't short of experience himself and has shown since his return from injury that he hasn't lost his pace.
Wilson is always full blooded in the tackle and likely to press Rollinson high up the pitch in order to win the ball back for City as soon as possible.
City's U18s will welcome Reading in the U18 Premier League with kick-off at 11am on Wednesday 3 May. Follow the match on mancity.com and @ManCityAcademy!