We take a 4-3 lead to Madrid following an unforgettable first-leg at the Etihad Stadium eight days ago.
To whet your appetite for tonight's decider, we look back on five of our most impressive goals in the competition so far in this campaign.
Bernardo Silva features twice thanks to his thumping strikes against Sporting and in last week's first leg against Real Madrid.
Kevin De Bruyne's crucial winner against Atletico de Madrid rounds out the top five.
Which is your favourite? Watch the video now to relive City's best Champions League goals in 2021/22!
Real Madrid v City
We will have full coverage of Wednesday's game right here on the official Man City app.
Our Matchday Centre gets under way at 18:00 (UK), providing you with live text updates.
Matchday Live will start around 18:45 when team news is announced. Trevor Sinclair and Nedum Onuoha are our studio guests for that one.
You can also enjoy full match commentary with Ali Mann and Andy Morrison.
Highlights will be available at 23:00 and CITY+ subscribers can watch a full 90-minute replay from midnight.