We host Graham Potter's men on Wednesday 20 April, with kick-off scheduled for 20:00 (UK).
After losing six successive Premier League matches, Brighton have turned their form around in recent weeks, picking up impressive wins away to Arsenal and Tottenham.
But with City keen to get back to winning ways following Saturday's FA Cup semi-final defeat to Liverpool, everything points towards a thrilling encounter at the Etihad Stadium.
Ahead of the clash, take a trip down memory lane by enjoying some sumptuous strikes from our previous fixtures against the Seagulls, including a thunderbolt from Sergio Aguero.
As always, we’ll have comprehensive coverage of City's Premier League clash with Brighton on mancity.com and the official app.
Kick-off is scheduled for 20:00, with live updates beginning in our Matchday Centre two hours prior.
Matchday Live, with special guests Michael Brown and Nedum Onuoha, gets under way one hour ahead of the action, while you can also listen to live audio commentary with Alistair Mann and Shaun Goater.
A detailed match report and post-match reaction from players and Pep Guardiola will also be made available shortly after the final whistle.
Both free to watch highlights and a CITY+ full-match replay can also be accessed from midnight.