Could City's superb start to the campaign continue against a side who twice denied the Blues victory in the Premier League last season?
Southampton left with a clean sheet in this fixture last season, but City looked determined to ensure that didn't happen again this time around.
Though Saints did hold out for 20 minutes, Joao Cancelo finally broke the deadlock with a clever run and finish.
Phil Foden doubled the lead 12 minutes later and there would be further strikes from Riyad Mahrez and Erling Haaland after the break as the Blues secured a 4-0 victory to move back to the top of the Premier League.
Watch the brief highlights of the game on the video above...
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