A brace of goals in both halves from Gunners striker Pierre-Emerick Aubameyang was enough to condemn Pep Guardiola's side to defeat.
It was a disappointing evening - made all the more so as it was our first taste of defeat in domestic Cup competition for more that two years.
City created a number of chances but ultimately it was Aubameyang's two strikes that proved the difference.
Now, after our final two Premier League games, the focus will be trained on our Champions League last 16 decider against Real Madrid next month.
Play the video to watch the best of the Wembley action...