Jack Grealish headed in the opener on the hour mark, before Bruno Fernandes and Marcus Rashford struck swiftly to hand the hosts the three points.
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Akanji admitted that the performance was a huge improvement from the midweek defeat in the Carabao Cup to Southampton, but still believes there is room for improvement.
"We played really well. The second half was better than the first half," he reflected.
"We did some changes and we dominated then we deservedly scored the first goal.
"After 1-1, we've got to be clear in the head, and defend for a couple of minutes and just calm down and then attack again.
"We didn't do it well today. I hope we can improve on that in the next game."
The Swiss international gave his opinion on the controversial equaliser by Fernandes and looked ahead to the next match against Tottenham Hotspur.
Watch the entire interview via the video at the top of the page.