The Champions fell to a 2-1 defeat to neighbours United, courtesy of first half goals from Marcus Rashford and Anthony Martial, leaving Guardiola's side 14 points adrift of Liverpool in the title race.
However, the Catalan boss asserted that even if things don’t go City’s way this term, the battle will resume next season.
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“We have to continue,” he said. “If we are not able to (catch Liverpool), then we want to try next season.
“Sometimes you don't win, the others are better, and you lose. The normal thing is not winning all the leagues and trophies.
“Sometimes you lose. The important thing is to not give up.
“In all the games we have played this season, we have played how I want us to play. When we struggle – OK - but it’s part of the process, maybe next season we will be better.”
Hear Pep's comments in his post-match press conference above...