Son Heung-Min’s 55th minute strike ultimately proved the difference and was enough to hand the hosts all three points as our Tottenham Hotspur Stadium hoodoo continued.
City had our chances – especially in a dominant first 15 minutes – but we failed to make that early pressure tell and ultimately it proved to be an afternoon of frustration for Pep Guardiola’s reigning champions.
As ever, anticipation and expectation were at fever pitch at the start of the new campaign and all eyes, of course, were on summer signing Jack Grealish who was handed his City Premier League bow.
And inside three minutes there was a thrilling early glimpse of the England man’s power and panache as he drove at the Spurs backline and was upended just outside the box.
With City immediately on the front foot, skipper Fernandinho then sent a 10-yard header agonisingly wide from a teasing Gundogan ball before Joao Cancelo miscued a close-range shot after superb work by Riyad Mahrez.
It was an imposing, dominant start with City’s fluency and fluidity already encouragingly evident against a dangerous Spurs side who weren’t averse to showing a muscular approach.
The only thing missing was a goal.
But with the hosts settling down after a testing start, there was a reminder of the threat posed by Nuno Espirito Santo’s men midway through the first half.
However, just at the point of contact, the Algerian slipped and his subsequent shot sailed harmlessly wide.
In a breathless first 45 it was then Spurs’ turn to threaten, a deflection off Joao Cancelo’s backside enough to ensure Son’s 20-yard shot missed the target.
It was Spurs who turned up the attacking ante after the break and it was danger man Son who broke the deadlock on 55 minutes.
Another Spurs counter put City on the back foot and Bergwijn found the South Korean on the right flank. He cut inside before curling a left foot shot beyond Ederson into the far-right corner of the net.
There was then a huge let-off for City after another lightning Spurs break.
A deflection sent an inviting ball into the path of the advancing Bergwijn but, fortunately, his 12-yard shot rippled the side netting after Ederson rushed out to narrow the angle.
And the Spurs keeper was there again to palm away a goalbound effort from Kevin De Bruyne, who was sent on as a late substitute and added fresh impetus to our attacks.
But the hosts held on to make it a frustrating start to our title defence as we suffered a fourth straight loss at Spurs' new stadium.
SPURS: Lloris, Tanganga (Doherty 89), Sanchez, Dier, Reguilon, Skipp, Hjojberg (Romero 89), Bergwijn (Lo Selso 77), Alli, Moura, Son
Subs: Winks, Gil, Sissoko, Gollini, Davies, Scarlett