It proved to be a tough afternoon in a game played in Monza, Italy due to COVID-19 restrictions, with Gareth Taylor’s charges were made to pay for a number of missed opportunities with the Spanish side proving clinical in front of goal.
Asisat Oshoala and Jennifer Hermoso, plus a Mariona Caldentey penalty put the Catalan side firmly in the driving seat as City suffered a first loss in 17 games.
To add to the frustration, Chloe Kelly also saw a second half penalty saved when the score was still 2-0.
It all leaves City facing a tough task when Barca visit the Academy Stadium for next Wednesday’s second leg decider.
You can watch full-match replays of every City game with a CITY+ subscription.