The England international reached the milestone in the Continental Cup Final clash with Chelsea at Wimbledon's Plough Lane.
The right-back - widely regarded as the best in the world, having been named in FIFPRO's World XI on four occasions - achieved the milestone in her second spell at the Club.
Powerful, pacey and driven, Bronze has played a key role in the Club's success, lifting four trophies, and helped Olympique Lyonnais to a golden period of silverware between 2017 and 2020, including European glory.
Reflecting on her milestone, she expressed her pride, having accomplished the feat for the first time.
"I've never played 100 games for anybody so it's nice to finally do it," she told mancity.com. "It's special.
"I'd seen that Ellie Roebuck got her 100th and jokingly said it must be mine next - and it is!
"For me, it's about how many trophies I can win in that time but it's nice to get a milestone in my career."
In her 100 games, the three-time Champions League winner has completed a clean sweep of domestic honours, winning the FA Women's Super League title, Conti Cup and FA Cup, scoring in two Cup Finals.
Having first joined the Club in 2014, she spent three years at the Academy Stadium and played an integral part in the team’s double-winning campaign of 2016.
Her own efforts during that season meanwhile saw her named PFA Women’s Players’ Player of the Year, FA WSL Players’ Player of the Year and City’s Women’s Player of the Season.
During her time in Manchester, she also flourished on the international stage at the 2015 World Cup, earning her country's Player of the Year award and a place in the World Cup All-Star squad. She also represented Team GB at the Olympic Games.
In 2018, she was named UEFA's Women's Player of the Year and then in 2020, claimed FIFA's TheBest Player gong, as her glittering collection of personal accolades grew.
Having suffered an injury at the start of the 2021/22 campaign, she has featured in every game since her return and has help to spark an upturn in fortunes for Gareth Taylor's side.
Many congratulations, Lucy!