Gareth Taylor's side will learn our Round of 16 fate at 11:00 UK (12:00 CET) on 16 February 2021.
City are amongst the top six highest UEFA coefficients and are therefore seeded.
The home team in each first leg will be decided by the draw.
Here's everything you need to know about the competition and the draw, which takes place in Nyon, Switzerland...
The Women’s Champions League is Europe’s elite club competition.
Originally named the UEFA Women's Cup, it debuted in the 2001/02 season before being rebranded for the 2009/10 campaign when, for the first time, the runners-up from the top eight ranked nations were able to participate.
The format of the final was also changed, becoming a single match played in the same city as the men's tournament as opposed to a two-legged contest.
Seven-time winners and current holders Lyon are the most successful club in the history of the competition.
Arsenal are the only English side to have won the tournament, defeating Umea 1-0 over two legs in April 2007.
The tournament involves the top club teams from countries affiliated with the European governing body UEFA.
In contrast to the men's tournament, there is no group stage in the current UWCL format.
The 16 teams have been divided into two groups of eight teams based on the following principles:
Seeding is based on club coefficient rankings, with an equal number of seeded and unseeded teams in each group.
No club can meet a team from their own association.
Covid-19 travel restrictions.
For each group, two bowls will be prepared, one containing balls with the four seeded teams and the other containing balls with the four unseeded teams.
The balls in both bowls will be shuffled. A ball will be drawn from each bowl and placed in a large empty bowl in the middle where they will be stirred.
The first team drawn will play its first match at home against the second team drawn. This procedure will be repeated until all the pairings in Group 1 have been drawn.
The same procedure is carried out with Group 2 to complete all eight pairings.
The two-legged matches will be played on 3/4 and 10/11 March.
Group 1: Seeded:
St. Pölten (AUS)
Group 2: Seeded:
Lyon (FRA holders)
Man. City (ENG)
City's European history
City made our Champions League debut in the 2016/17 campaign, having finished second in the FA WSL in 2015.
An incredible debut campaign saw Cushing's side reach the semi-finals, defeating Zvezda Perm (6-0 on aggregate), Brondby (2-1 agg.) and Fortuna Hjorring (2-0 agg.) before falling to the eventual competition winners Lyon (3-2 agg.)
City ended the 2016 domestic season as league and Continental Tyres Cup champions to qualify to the 2017/18 tournament. and repeated the success of the previous year, defeating St Polten (6-0 agg.), Lillestrom (7-1 agg.) and Linkoping (7-3 agg.) before once again being edged out by Lyon in the last four.
The 2018/19 would prove unsuccessful, as City fell at the first hurdle, losing to Atletico Madrid over two legs in the Round of 32, but the domestic cup double winners secured progression to our fourth successive European tournament with a top-two finish in the FA WSL.
The Spanish outfit would edge us out for the second successive season in 2019/20, as Cushing's side fell to a 3-2 aggregate defeat to the Primera División Champions at the last 16 stage, drawing 1-1 in Manchester before suffering a 2-1 reverse at the Centro Deportivo Wanda, courtesy of a Steph Houghton own-goal and a second half Angela Sosa strike.
Pauline Bremer netted a consolation late on but it would prove too little, too late, as the 2017 and 2018 semi-finalists were eliminated.
City reached the last 16 with a 5-1 aggregate triumph over Swedish outfit Göteborg FC.
Stanway bagged another two in the home encounter, after Lauren Hemp had broken the deadlock with a long-range wonderstrike.
Champions of Europe
For Lucy, it marked a hat-trick of European successes, as she claimed her third successive medal.
Joining City in September, the pair say they hope to help City and the FA Women's Super League become dominant forces on the continent.
Round of 16: 3/4 & 10/11 March
Quarter-final and semi-final draw: 12 March
Quarter-finals: 23/24 March & 31 March/1 April
Semi-finals: 24/25 April & 1/2 May
Final: 16 May (Gamla Ullevi, Gothenburg)