Gabriel Jesus, Bernardo, Benjamin Mendy, Joao Cancelo, Riyad Mahrez and Nicolas Otamendi all return, with Raheem Sterling, Ilkay Gundogan, Oleks Zinchenko. Fernandinho and Phil Foden all dropping to the bench.
Sheffield Wednesday starting XI: Wildsmith, Palmer, Iorfa, Börner, Fox, Pelupessy, Murphy, Lee, Bannan, Da Cruz, Forestieri
Subs: Harris, Fletcher, Lees, Nuhiu, Dawson, Hunt, Urhoghide
Formation and tactics: 4-3-3
City looking to continue domestic cup dominance
City will be just one game away from yet another Wembley appearance should victory be achieved over Garry Monk’s Sheffield Wednesday.
That, in turn, would put a second season of Community Shield, Carabao Cup and FA Cup successes firmly in view.
If City can complete a domestic treble of silverware, it would be an incredible achievement and one that hasn’t been done before.
The Premier League title might not be heading back to the Etihad this season, but if every other domestic piece of silverware did, it would be another fantastic campaign for Pep Guardiola’s side.
Owls look to halt slide
Just two wins from their last 13 Championship games has seen Sheffield Wednesday’s play-off hopes severely dented.
During that run, the Owls were thrashed 5-0 at home by Blackburn Rovers, but they have impressed prior to that with wins away to Leeds United and Brighton in January.
They haven’t become a bad side over night and will look to prove a point against the FA Cup holders with a crowd of around 25,000 (4,500 from City) watching on.
- City are unbeaten in their past 11 league and cup games against Sheffield Wednesday (won 7, drawn 4), winning the last three.
- Wednesday's most recent victory against City was 3-1 in a Premier League game at Maine Road in November 1993.
- All four previous FA Cup ties have been won by Manchester City (two after a replay).
- City have never lost to a Championship side under Pep Guardiola.
- City have won their last five FA Cup games against clubs from a lower division, scoring 22 goals in the process.
- Gabriel Jesus has been directly involved in 11 goals in his eight FA Cup appearances (scoring seven and assisting four), including six in his last three (five goals and one assist).
- Bernardo Silva has four goals and four assists in his last nine FA Cup appearances.
- The Owls last reached the FA Cup quarter-finals in 1997 and have lost five successive fifth-round ties.