City welcome Julen Lopetegui's side to the Etihad Stadium on Sunday 22 January, with kick-off scheduled for 14:00 (UK).
Victory would move Pep Guardiola's men within two points of the Premier League summit for a few hours at least, ahead of leaders Arsenal's clash with Manchester United later in the day.
City go into the tie on the back of a dramatic 4-2 comeback win over Tottenham on Thursday night.
A Riyad Mahrez brace plus further strikes from Julian Alvarez and Erling Haaland were enough to overcome a two-goal first half deficit, but a resurgent Wolves side are sure to offer another stern test of our credentials.
Indeed, the visitors have lost just once in the Premier League since the Spaniard's appointment, slowly dragging them away from the bottom three.
It leaves FPL managers with plenty of tough selection decisions to make ahead of Saturday 21 January's 11:00 deadline.
Check out the latest Scout Report below…
Kevin De Bruyne (£12.5m) could pose huge problems for Wolverhampton Wanderers in Gameweek 21 of Fantasy Premier League.
The Belgian looks set to return to the starting XI this weekend after being rested for Manchester City’s 4-2 win over Tottenham Hotspur on Thursday evening.
De Bruyne has an outstanding recent record against the midlands outfit.
He has four goals and two assists across his last two meetings, including his career-high haul of 24 points at Molineux last season.
The underlying statistics further highlight De Bruyne’s influence on the City attack.
His 58 key passes and 20 big chances created are both team-leading totals in 2022/23 and are also more than any other player in Fantasy.
Ones to watch
Daniel Podence (£5.3m) has been the visitors’ standout player since the season resumed, scoring in three of their four matches under new head coach Julen Lopetegui.
Only Wolves goalkeeper Jose Sa (£5.0m), has picked up more points than the winger this season.
Elsewhere, Rodrigo (£6.4m) and Eddie Nketiah (£6.5m) could be overlooked gems in Gameweek 21.
Rodrigo hosts Brentford on the back of six goals in his last eight outings for Leeds United.
Arsenal’s Nketiah faces a Manchester United outfit who are without their influential midfielder Casemiro (£4.9m) through suspension on Sunday afternoon.