Pep Guardiola's men travel to the King Power Stadium for Saturday's 12:30 (UK) kick-off knowing victory would move us to the Premier League summit for at least 24 hours.
It's a quick turnaround for City having secured top spot in Champions League Group G with a goalless draw against Borussia Dortmund on Tuesday.
And with Leicester unbeaten in each of their last three home matches after a difficult start to the season, we are sure to be pushed to our limits in the midlands this weekend.
Everything points towards an exciting encounter, leaving FPL managers with plenty of opportunities to pick up the points.
Check out our latest Scout Report below ahead of Saturday's 11:00 (UK) deadline...
A rested Kevin De Bruyne (£12.3m) looks set to pose big problems for Leicester City in Gameweek 14 of Fantasy Premier League.
The Belgian was an unused substitute in City’s goalless draw with Borussia Dortmund in the UEFA Champions League in midweek.
That lifts his chances of returning to the champions’ starting XI for Saturday lunchtime’s encounter at the King Power Stadium.
The underlying numbers show his huge influence on the road this season.
Away from home, De Bruyne’s totals of 19 key passes and eight big chances created are both more than any other player in Fantasy.
Opponent to watch
James Maddison (£8.2m) is the Foxes’ form player, with four goals and an assist in his previous five appearances.
The midfielder has amassed 36 points during that time.
Elsewhere, Dominic Calvert-Lewin (£7.9m) and Callum Wilson (£7.2m) provide managers with strong differential options.
Everton’s fit-again Calvert-Lewin visits Fulham on the back of his first goal of the season last weekend.
Wilson has four goals in eight outings ahead of Newcastle United’s home clash with Aston Villa.