The Belgian opened the scoring with a driven finish, before restoring City's lead from close-range after Leander Dendoncker equalised for the hosts.
The 30-year-old completed his hat-trick after 24 minutes, bursting through challenges before arrowing a shot into the corner from 18 yards.
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On the hour mark, he got his fourth with an accurate strike inside the box, before Raheem Sterling scored a late fifth. The midfielder was left delighted after a landmark evening.
"It was pretty nice. When you score four goals it’s always something special," he said. "It should have been five to be honest! I think we played well and controlled the game really well," the Belgian reflected.
"I think the third one [best goal]. That strike is the cleanest. I hit it really hard in the corner. Out of the three that was the purest I’d say. If you miss you miss, you have to go for the opportunity.
"It’s just whenever you get the opportunity you don't hesitate. I’m never afraid to shoot with my left. Even if it doesn't go in, it creates a problem for the opposition.
"We could have scored more, to do that against Wolves who are defensively sound was impressive. Our front four found the right moments.
"Phil [Foden] and Raheem [Sterling] have such good movement in behind that it worked really well, the team worked really well.
"Central, I'm the best," added De Bruyne when quizzed on his favourite position. "I think that’s probably my best position.
"But playing in a different position I learned how to understand what my teammates want."
The win moves City three points clear of title rivals Liverpool at the top of the league table, with a seven goal difference advantage after the win at Molineux.
However, De Bruyne believes that City need to simply remain focused on the next game against West Ham on Sunday.
"Obviously we know at the moment, we know we have a little bit of an advantage with the goal difference," De Bruyne added.
"I think we just need to concentrate on Sunday at West Ham, it’s going to be a tough game, we need to recover and be ready.
"It’s crazy. The standards we both set, you have to respect it. I think both teams have ultimate respect and we play hard. That's the only thing we can do, now we have to prepare ourselves, it's not going to be an easy game against West Ham.
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"It’s very difficult to explain because it was a mad five minutes, It’s not that we played bad or something," the midfielder added when reflecting on the heartbreaking Champions League semi-final exit earlier this month.
"I don’t know what happened. I was on the bench anyway, but you feel a shock, it’s not nice, but you need to move on. We’re trying to win the title now. You have to move on."