Pep Guardiola’s men lock horns with the Mexican side at Houston’s NRG Stadium on Wednesday 20 July, with the match available to watch live on CITY+.
It will be the first time that the two sides have faced each other since 2011, with Lescott part of the team who beat the Eagles 2-0 in San Francisco on that occasion.
But the former England international expects City to be handed a stern test as preparations continue for the new 2022/23 campaign.
“In this part of the world, they have a huge reputation, they are a globally established team,” Lescott explained.
“My first time in Houston was actually against Club America for Everton. In regard to what they’re about, they’re very good technically.
“They’re also further along in their season, hence why you come to this part of the world to play teams, it gives you an indication of where you are.
“It won’t be easy. They’ll be used to the climate more than our boys as well so I’m sure that will need to be considered in terms of minutes and selection."
With the Mexican top flight having already got under way, Club America come into the tie on the back of one win, one draw and one defeat from their opening three matches of the season.
And Lescott believes facing a side in peak physical condition could prove vital in the early weeks of the campaign.
He said: “(You’re facing) new teams and new players, but also again different stages.
“You’ll probably train against your teammates and think ‘I’m doing alright’ but you’re all at the same stage and have come back with the same amount of training.
“So, when you play a team that’s three or four months ahead, you realise you’re not quite where you need to be.
“That helps you recognise that side of it, but the objective isn’t to put in a world class performance, it’s to get through the minutes and get used to reacting again.
“As players you can do all the training you want but in a game you actually react and get that competitive edge again.”