De Bruyne and Foden have been selected as part of a six-strong Premier League shortlist, while Greenwood's stellar displays have given her a nod in the FA Women's Super League category.
Both members of Pep Guardiola's squad have been at the centre of our push for back-to-back Premier League titles.
Indeed, De Bruyne and Foden have contributed to 36 of our 96 Premier League goals so far this campaign, as we aim to seal the title with victory over Aston Villa on Sunday.
2021/22 represents De Bruyne's best goalscoring season in the English top flight, with the midfielder on target 15 times across the campaign including crucial strikes against Liverpool, Chelsea and Manchester United.
He also became only the third midfielder in Premier League history to score four goals in a single match when Pep Guardiola's men came away from Molineux with a 5-1 win over Wolves.
The Belgian has also made the three-man shortlist for the Etihad Player of the Season award, alongside Bernardo Silva and Riyad Mahrez.
Foden is also on course for the most fruitful campaign of his young career to date, with his nine goals and five assists matching his total from 2020/21.
Last season's PFA Young Player of the Year recovered from a footy injury sustained during last summer's European Championships to continue his rapid rise for City.
One of Foden's standout performances saw him grab a crucial equaliser in our 2-2 draw at Anfield back in October in what was a man of the match display.
And the 21-year-old was also on target in crucial 1-0 victories away to Brentford and Everton.
Our City stars are up for the award against Declan Rice (West Ham), Conor Gallagher (Crystal Palace), Mohamed Salah and Trent Alexander-Arnold (Liverpool).
Despite an unprecedented injury crisis, Greenwood was an ever-present for Gareth Taylor's side across 2021/22.
The defender played a crucial role in City securing Champions League football next season, helped by a phenomenal run of 21 wins in our last 24 matches in all competitions.
And while the season ended in FA Cup heartbreak at the hands of Chelsea, Greenwood and co. did finish the campaign with a deserved piece of silverware after getting the better of Emma Hayes' side in March's Continental Cup final.
Not only was Greenwood a key cog in our defensive machine, but the centre-half also provided five goals and five assists from centre-back.
She faces stiff competition from Sam Kerr (Chelsea), Beth Mead, Vivianne Miedema (Arsenal), Ella Toone and Alessia Russo (Manchester United).