Trent Alexander-Arnold opened the scoring after 21 minutes, with City debutant Julian Alvarez netting the equaliser with 20 minutes remaining after coming on from the bench.
A Mohamed Salah penalty and late Darwin Nunez header secured the victory for Liverpool.
With this only being City's third pre-season fixture since the end of last season, Ake admitted it's still very early in the season for any worry to creep into the City camp.
"Everyone worked hard," he said. It’s still very, very early in the season.
"It’s now about the next few weeks, getting our rhythm and then start to go.
The centre-back played the entire 90 minutes in Leicester and despite admitting it is a bitter pill to swallow, he believes there are definitely positives to take from the game into the new campaign.
"I think it was two very good teams so it’s always going to be tough," he revealed.
"It’s difficult for us to take. I think there were periods where we played well and periods where they were better. After the 2-1 it became difficult.
"I think to be fair, after 1-1 we played well, before that as well we kept the ball well, created chances and big opportunities.
After 2-1 it was difficult to come back. They were solid defensively and it’s a difficult game to take."
Pep Guardiola's side kick off the defence of our Premier League crown next Sunday, away to West Ham United.