The Argentine was introduced at the Etihad Stadium with just 25 minutes remaining and found the back of the net twice in superb fashion.
The striker scored City's fourth of the afternoon after some neat footwork inside the box, before accurately directing the ball into the far corner with the outside of his right foot.
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He then made it 5-0 with a trademark run and header as he signed off in Premier League terms in fairytale fashion, becoming the league's top goalscorer for a single club and he expressed his delight at full time.
"This match is my last game but, I am so happy," he admitted. "I want to thank my teammates because they have helped a lot. Thank you for everything.
"I’m a striker, my target is to score goals so I’m so happy because finally in my last game to get two more goals is fantastic for me."
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The 32-year-old has enjoyed a stellar decade at the club, winning 15 major trophies and the prolific striker spoke about his honour at playing for the club.
"For me when I came here I didn’t know what would happen. The first title was the most important for the club and me. Then City started to win many titles.
"I’m so happy because it’s not easy to be ten years at one club. So for me it’s an honour.
"Before the game, I felt so strange. The sensation is not good, but I prefer to think and enjoy the moment."
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There is still one more match remaining in his City career, as City play Chelsea in the UEFA Champions League final next weekend in Porto, and the forward is ready to play his part if called upon by Pep Guardiola.
"I hope, but I don’t know, if I will play a few minutes, I will give my best because I love football."