When and where
City play host to our French league opponents in our opening Champions League Group F clash at the Etihad on Wednesday 19 September, kick-off at 8pm (BST).
The match will be shown live in the UK on BT Sport 3 while fans around the world can find out where they can watch the match with our TV listings…
Kevin De Bruyne is out after sustaining a lateral collateral ligament (LCL) lesion in training.
Claudio Bravo is also unavailable, having sustained an Achilles tendon injury. The Chilean 'keeper underwent scans, which confirmed a rupture in the tendon of his left foot.
Sergio Aguero was back in training ahead of the game, after he came off during the 3-0 win over Fulham on Saturday due to an ankle problem.
Benjamin Mendy, who missed the win over Fulham with a knee problem, did not train and remains doubtful for the game against the Ligue 1 side.
Striker Amine Gouiri is sidelined for the long term having sustained a ruptured cruciate ligament injury
New signing Moussa Dembele, who joined the club from Celtic on September 1, made his debut coming on as a substitute at the weekend and is available.
This will be the first-ever meeting between the two teams
Last time out
City made it four wins out of five in the Premier League with a hugely impressive 3-0 win over Fulham at the Etihad on Saturday.
Lyon, meanwhile, played out a 2-2 draw in Ligue 1 away to Caen. Nabil Fekir and Ferland Mendy were on the scoresheet.
Mikel Arteta, who will stand in for the suspended Pep Guardiola on the touchline at Wednesday's Champions League Group F opener against Lyon addressed the media ahead of the clash.
Aymeric Laporte was also at the press conference on Tuesday afternoon...
• City won all three home games in last season's group stage, including a 2-0 defeat of Shakhtar Donetsk, who are again among the opposition this season. We had won seven of our previous eight home European matches, including four in a row before losing to Basel.
• City's best performance was reaching the 2015/16 semi-finals; this is our eighth consecutive appearance in the group stage.
• The Blues' home record against French clubs is W2 D1, although our most recent match, a 5-3 defeat of Monaco in the 2016/17 UEFA Champions League round of 16 first leg, led to elimination on away goals after a 3-1 second-leg loss in France.
• Lyon's Ligue 1 record this season is W2 D1 L2 – both victories by a 2-0 scoreline, and both defeats 1-0.
• Saturday's 2-2 draw at Caen was Les Gones' first in all competitions since 4 March; their record in between was W12 L4.
• Nabil Fekir played in six of France's seven games during their victorious FIFA World Cup campaign this summer, all as substitute including in the final defeat of Croatia.
•Lyon are in the group stage for the third time in four seasons – their 2015/16 and 2016/17 campaigns both ended at that hurdle.