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The Riverside Stadium is the venue for this tie, which kicks off at 12:15pm GMT.
The game will be broadcast live in the UK with BT Sport 2's coverage getting under way at 11:45am on Saturday morning.
For fans outside the UK, click here to find out how you can see the action.
You can also follow the game here on our website or our Matchday App.
For the home side, centre-backs Daniel Ayala and Calum Chambers are Aitor Karanka's only two absentees.
City were denied victory over Middlesbrough earlier in the Premier League season in a dramatic 1-1 draw.
This brought the visitors out in the second period and although both sides had their chances, it was Middlesbrough who scored in added time through Marten de Roon's header.
Yaya Toure says he wants to win this season's FA Cup and has cited the Club's 2011 triumph as the catalyst for City's recent success.
“The goal against Stoke [in the 2011 FA Cup final] was important,” he said. “The first year I came to City, the manager told me it was very important to come because they were going to attract some big players and people were going to look at City differently.
“People looked at City as a big club – but a money club, just trying to buy players. But I was very delighted to come because my target was to try and be part of the story of this club."
And Willy Caballero says City need to forget the disappointment of the draw with Stoke and focus on winning the FA Cup.
“We lost two points that we should win, and this is a pity,” he said. “Our next goal now is the FA Cup.
“We know that if we win on Saturday we will be at Wembley, in the semi-finals, which means we bring our fans there. This is what we want and enjoy the most."
TV listings for Middlesbrough v Manchester City in the FA Cup.
Iheanacho pleased with City's display against Stoke