The talented 20-year-old has been side-lined with a muscle pull and is yet to play for the Blues since his summer move from Schalke.
But the winger Germany boss Joachim Low says is a “special talent” is fit and raring to go – if selected.
“I feel good now and I think I’m ready to play,” said Sane. “I’ve trained well and my hamstring is fine so I’m looking for to finally getting started.”
With Sane and compatriot Ilkay Gundogan both yet to feature for City, there is a possibility both German stars may get some game time under their belts at Old Trafford.
Sane, who has featured in the fierce ‘Revierderby’ between Schalke and Borussia Dortmund (Sane v Gundogan), believes the fact that former Real Madrid boss Jose Mourinho and former Barca boss are now in charge of the Manchester rivals adds a new dimension to what was already a potentially pivotal Premier League fixture.
He said: “I’ve played in derby games in Germany but this should be a great match and one I’m really looking forward to, especially because is taking on Jose Mourinho.
“It should be a special game and we can sense the expectation all around the city from our supporters.
“I can’t believe how close the two clubs are and it’s maybe ten minutes to drive from City to United which is really quick! In Germany it was about 30 minutes between Schalke and Dortmund but Manchester is different.
“It goes without saying that everyone wants to win this game, particularly so early in the season and both sets of supporters will be afraid of losing, but that’s normal for any derby – nobody wants to end on the losing team.
“On the other hand, I think some fans would be happy to end the season there and then if they end up winning!
“It’s going to be exciting and I hope I can play some part and help us bring back three points.
“It will be tough. I think both sides will play their own game, keep the ball and look for openings and the team that plays the best football will probably win and we intend that to be us.”