John Stones and Fernandinho also return to the matchday squad but start on the bench.
Pep Guardiola makes four changes from the Blues’ last game – a 3-2 win at Swansea – with Riyad Mahrez, Fabian Delph, Leroy Sane and Gabriel Jesus all making way for De Bruyne, Oleks Zinchenko, Raheem Sterling and Sergio Aguero.
Ederson, Walker, Zinchenko, Laporte, Otamendi, Gundogan, De Bruyne, D Silva, Bernardo, Sterling, Aguero
Subs: Muric, Danilo, Stones, Sane, Fernandinho, Mahrez, Jesus
It looks like Sterling and Bernardo will support Aguero in attack, with Ilkay Gundogan retaining his anchor role in midfield alongside David Silva and De Bruyne.
Nicolas Otamendi and Aymeric Laporte resume their central defensive partnership.
Title race resumes….
City know how important it is to pick up three points today.
The Cottagers are 13 points from safety with only 21 points to play for – the Blues can’t afford to drop any points at Craven Cottage where Liverpool won 2-1 before the international break.
Under caretaker boss Scott Parker, Fulham have certainly improved and become more compact – but City have to win and pile the pressure back on Liverpool who play tomorrow against Spurs.
The last time...
Milestones and stats
City have won the past six league meetings. Between the two teams.
Fulham's last win in this fixture came in 2009 – a 3-1 win at the Etihad.
The Blues have scored in 23 successive games against Fulham.
The Cottagers have lost 11 out of their last 12 matches in all competitions.
Fulham have conceded 70 league goals this season, more than any other top-flight side.
Raheem Sterling has scored eight goals in his last four starts for club and country.