It's the Stockport-born midfielder's first Premier League start of the campaign.
XI: Leno, Maitland-Niles, Chambers, Sokratis, Kolasinac, Guendouzi, Torrera, Pepe, Ozil, Martinelli, Aubameyang
SUBS: Martinez, David Luiz, Willock, Nelson, Smith Rowe, Saka, Lacazette
XI: Ederson, Walker, Fernandinho, Otamendi, Mendy, Rodri, Gundogan, Foden, De Bruyne, Sterling, Jesus
SUBS: Bravo, Zinchenko, Angelino, Bernardo, Mahrez, Cancelo, Garcia
It’s the usual 4-3-3 for City.
Ederson is protected by a back four of Walker, Fernandinho, Otamendi and Mendy, with Rodri offering additional protection just in front of them.
Foden and Ilkay Gundogan will bring quality in guile in midfield, and Raheem Sterling and Kevin De Bruyne will play just off Jesus.
It's a side packed with quality and attacking intent, whose primary focus will be dominating possession and controlling the game.
City will need to be solid. Arsenal may not be in the best form, but they remain a side with plenty of goalscoring threats, particularly Pierre-Emerick Aubameyang, who has scored 13 goals in 20 matches this term.
Arsenal have lost their last five games against Manchester City, including the 2018 League Cup final, which gave Pep Guardiola his first trophy in charge.
The other four defeats came in the league - Arsenal haven't lost five consecutive top-flight matches against one side since doing so versus Manchester United between September 1983 and August 1985.