City travel to Old Trafford, looking to take another step towards the Premier League title, having defeated Tottenham 1-0 on Saturday.
Phil Foden’s early header separated the sides at the Etihad Stadium but the triumph was marred by an injury to De Bruyne, which forced the Belgian to be substituted.
WATCH: Inside City | Episode 338
"I don't know,” he stated. “I didn't speak with him or the doctors.
"It was something muscular, which is normal after injuries and three or four games of a lot of minutes with no preparation.
"Maybe he will miss the four games and the FA Cup Final. I don't know how big the impact is.
"We will see tomorrow but I think for the next game, he will be out."