The Argentine striker, who provided the assist for Raheem Sterling’s strike, was substituted on 53 minutes for Gabriel Jesus, having suffered a knock in the first half.
Guardiola admitted it is too early to know whether the forward will feature in the midweek Champions League clash with Lyon.
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“It was something in the ankle,” the Catalan boss told press.
“He went up to head a cross and when he fell down, he felt something.
"He finished the first half and started the second half a bit uncomfortable.
“He could have played on but with us winning 3-0, we did not want to take a risk (so he was substituted). We will see tomorrow (if he can play on Wednesday).”