The Belgian midfielder was again at his imperious best for Pep Guardiola's side, producing another man-of-the-match display and scoring the crucial opening goal which broke the first-half deadlock.
Arsene Wenger's Gunners played their part in a high-quality game but were always second best to City. Sergio Aguero doubled City's lead with a second half penalty before Alexandre Lacazette reduced the arrears.
But Gabriel Jesus's 72nd minute strike secured the three points to ensure a ninth-straight league win and stretch City's lead at the top of the Premier League table.
And with the league now on hiatus for a fortnight due to the November international break, De Bruyne believes it was another example of City's belief and mental strength this season.
"We know Arsenal are a quality side but I think we contained them quite well," said KDB.
"We kept our composure well and it is a great win for us.
"We created more chances and the third goal came at a good time. We should also have scored the second one in the first half.
"Obviously, it was great to score as it put us ahead and it's always nice every time you score.
"Maybe we got the benefit from the referee but the penalty was the second one of its type in the game. He had to give a penalty.
"The more you win, the more other teams want to beat you. It's been a great start for us so let's see what other games bring."