Two of the WSL's in-form teams will lock horns in what promises to be an historic encounter.
Gareth Taylor's side have won each of our last six matches in all competitions, scoring 20 times in the process, while the visitors have lost just once all season.
The two teams boast nine members of the victorious England squad from this summer's European Championships, while City can also call upon the WSL's top scorer in Khadija 'Bunny' Shaw - who has eight goals in just seven games so far.
Something has to give when the two sides face each other on Sunday 11 December, with kick-off scheduled for 12:30 (UK).
And with the World Cup currently taking place in Qatar - it also represents the next opportunity for City fans to get your football fix at the Etihad!
Tickets are selling fast, with almost 40,000 already snapped up ahead of the fixture, so make sure to get yours as soon as possible!
Having first locked horns with Everton back in May 2014, City first welcomed United to the Etihad in September 2019.
Caroline Weir proved to be the hero on that occasion, with her wonder strike seeing us run out 1-0 winners in front of what was then a WSL record, and remains a Club record attendance of 31,213 fans.
With the latest encounter taking place in just two weeks, be sure to get your tickets and be part of another historic occasion.
You can secure yours online by visiting: www.mancity.com/tickets/womens or by calling: +44 (0)161 444 1894.