Where and when
The game kicks off at 16:30 GMT on Sunday 15 December at the Emirates Stadium.
And if you miss the game, or just want to watch it back, the match is available in full within 24 hours of the final whistle via Man City for TV.
John Stones (hamstring) and Sergio Aguero (muscular) will both miss the game, while Pep Guardiola is unsure whether David Silva will recover in time from the injury he picked up against Manchester United.
Long term absentees Aymeric Laporte and Leroy Sane remain sidelined.
Pep Guardiola's preview
"We'll watch the previous games with Unai [Emery] and now [Freddie] Ljungberg and we'll figure out what they will do. Arsenal have a typical style of play.
"They have quality between the lines with [Mesut] Ozil and [Alex] Lacazette. Arsenal away is always a test for any team."
Referee: Paul Tierney
Assistants:Constantine Hatzidakis and Harry Lennard
Fourth official:Andre Marriner
Assistant VAR:Sian Massey-Ellis
Last time out
City come into the game on the back of a comfortable 4-1 win away at Dinamo Zagreb in the Champions League, whilst Arsenal, having already qualified for the knockout stage, were held to a 2-2 against Standard Liege in the Europa League.
Sergio Aguero's 14th hat-trick for the club earned Manchester City a 3-1 win over Arsenal at the start of February.
The Argentine struck within the first minute before Gunners captain Laurent Koscielny leveled ten minutes later.
But Aguero was not to be stopped, grabbing his second on the stroke of half-time before poking home Raheem Sterling's cross after the hour mark.