City have mostly played one up front during Pep Guardiola's reign, but adopted a 3-5-2 formation against Huddersfield with the South American strikers grabbing four goals between them.
Jesus says he and Aguero have proved they can play alongside each other on numerous occasions over the past 18 months.
He said: “Our team has six players capable of playing in the attack, all of them really good.
"Pep opted for Sergio and myself, just like he has done last season and I think there was only one match where we didn’t so well - but usually when we both play together we do a great job.
"We can indeed play together!
“Sergio and I have the spirit of scoring goals and always try to finish well. I’ve started this season with the aim to get better with my finishes, to keep helping the team.
“Pep is super intelligent and he knows what the team needs and when and of course, I’ll be always at his disposal whenever I'm called upon. I’ll always keep the same spirit.
“Our season started really well against Arsenal last week, especially as it was away which obviously made it even harder.
"We wanted to start strongly at home and our team did a great job against Huddersfield - we did what we’ve been practising and were asked to do, and the result is there.”
Jesus added that the margin of win on Sunday was nothing other than a good display by the Blues, saying there is no need to leave 'markers' for title rivals.
“We don’t play to leave a message to anyone, just like last season," he said,
"We play because we love doing it, we’re at a great club and we want to keep writing history for Manchester City.
"So we must carry on, repeat what we’ve been doing and see where it takes us.
"It will be tough, but this is why we’re here."