Manuel Pellegrini has made just one change from the side that beat Dynamo Kyiv in midweek with, as expected, Willy Caballero replacing Joe Hart.
That means full-backs Bacary Sagna and Gael Clichy get the nod over Pablo Zabaleta and Aleksandar Kolarov.
Whether Fernandinho gets the nod to play on the right of a three-man midfield again or not remains to be seen, but the experiment against Kyiv worked so well it could be the Brazilian reprises his role this afternoon.
If he does, Yaya Toure and Fernando will play holding roles in midfield with Raheem Sterling and David Silva joining Ferna as a three-pronged attacking midfield trio behind Sergio Aguero.
Caballero, Sagna, Kompany (C), Otamendi, Clichy, Fernando, Fernandinho, Toure, Silva, Sterling, Aguero
Subs: Hart, Kolarov, Zabaleta, Demichelis, Navas, Iheanacho, Bony
Bony and Navas return
Wilfried Bony makes a welcome return on the bench after an eight-week absence and provides valuable additional attacking options for the Blues.
Jesus Navas is also fit enough to be named among the subs after nearly a month out with a hamstring strain.
Only five of today’s starting line-up remain from the 4-1 thrashing the Blues suffered to Liverpool last November. Only Sagna, Fernandinho, Yaya Toure, Sterling and Sergio Aguero remain.
Liverpool starting line-up
Starting XI: Mignolet, Clyne, Lucas, Sakho, Moreno, Can, Henderson, Milner, Firmino, Coutinho, Sturridge
Subs: Toure, Benteke, Lallana, Allen, Origi, Flanagan