The game at Selhurst Park sees first take on second in what is sure to be a tough test for Manuel Pellegrini's side.
City will be looking to maintain their 100 per cent start, while Palace will be aiming to follow up on their impressive victory at Chelsea before the international break.
The Eagles also flew off with the points last time they met City so there should be some scores to settle among the City team.
The headline team news is David Silva's absence with an ankle injury, but that could provide new boy Kevin De Bruyne with a platform on which to shine.
Need to know
Match: Crystal Palace (2nd) v City (1st)
Competition: Barclays Premier League
Date and time: Saturday 12 September 2015, 3pm BST
Referee: Mike Jones
Last time: Palace 2-1 City, 6/04/2015
Head to head record: City wins 24, draws 12, Palace wins 15
TV and radio: BBC Radio Manchester
Crystal Palace - WLWW
City - WWWW
Ticket info: Sold out
Out for City: David Silva (ankle), Fabian Delph (hamstring), Gael Clichy (ankle), Pablo Zabaleta (knee)
Out for Crystal Palace: Joel Ward (knee), Marouane Chamakh
Doubts: Conor Wickham
Manuel Pellegrini: “Kevin is an important player, like Raheem, he has characteristics we need.
"His position is easy to settle in our team. He will be a very important player for us. He’s in the squad list, we’ll see tomorrow whether he starts.
"He’s a young player and he’s improved a lot since he was last in the Premier League. I always say that when good players arrive into a good team with good players, I think that they will continue to improve and that’s why he’s here.
Wilfried Bony: “Crystal Palace will be very difficult and we lost there towards the end of last season. But our team is in a very good moment and we feel we can go anywhere and win.
"Palace’s start to the season hasn’t surprised me at all. They were always improving last season, have strengthened well during the summer and are stronger again this campaign.”
Crystal Palace manager Alan Pardew: "We're different to Manchester City. We have more counter-attacks than them. They tend to retain the ball sufficiently, they can dominate possession and how many times we can unlock the door on our breakaways will be the key."
City begin their Champions League campaign against last season’s finalist Juventus on Tue 15th Sept at 7.45pm. For a first glimpse of new signings Kevin De Bruyne and Nicolas Otamendi, make sure you’re there to support the team for what promises to be an exciting night of European football. Buy your tickets now or enjoy the game in the new 93:20 bar from £67 + VAT.