The nadir in the 2011/12 campaign came at the Emirates, when Arsenal’s Mikel Arteta fired a late winner which felt like the beginning of the end for City's title hopes.
We all know how that turned out.
The nature of Sunday afternoon’s defeat to Liverpool may have left some supporters feeling similarly funereal but Edin Dzeko knows better than most how quickly things can change at this late stage of the season.
Dzeko had already won the Bundesliga with Wolfsburg before his 90th minute equalising goal against QPR on the final day of the 2011/12 campaign which kick started that stunning finale.
Now the Bosnian believes that history can repeat itself two years later, with the league champions being crowned on the very final day.
“It’s too early to say if Sunday’s result will decide where the title ends up because we still have six games to play and Liverpool and Chelsea both have four left,” the 28-year old declared.
“People talk about pressure and suchlike but that doesn’t really matter – just who wins the most games between now and the end of the season.
"I firmly believe, like the last time we won the title, that it will go right to the wire despite our defeat at Anfield.”
What looks certain is that City won’t be afforded any more slip-ups if they are to capture a second title in three years.
Like in 2012, the Blues require a sprint finish, starting at the Etihad Stadium on Wednesday night when Sunderland are the visitors.
“It was an amazing experience to win the title in 2012 but that was then, this is now and everything is different,” Edin asserted.
“We have a lot of new players and we want to win it again for our fans, the team and the Club and we have to get back on track by beating Sunderland and West Brom in the next week.
“It is very difficult to win titles anywhere and the Bundesliga and the Premier League are among the hardest to win, but I enjoyed winning the league with Wolfsburg and it was amazing to win it with City and I hope to win it many more times as a City player.”
The Sarajevo-born frontman is enjoying his best goalscoring season in his four years as a City player, netting 21 goals in 41 appearances.
“The manager has brought some new things to the team. We are playing aggressive, attacking football and scoring a lot of goals,” Dzeko smiled.
“I’m very happy with the way things have gone so far and I’m enjoying my season.
“Sergio’s return is great for the team because he is such an important player for us.
"We hope we can see the very best of him in the games that remain.”
The race for the Premier League has come to the boil, so make sure you’re there to lend your support as we bid for a second title in three years.
Tickets are still available for the two of the last first-team games taking place at the Etihad Stadium this season, against Sunderland and West Brom.
They could be decisive clashes, so don’t miss out.