Victory against the Londoners would be enough to secure a third Premier League title in four years, but we will need to be at our best to make that ambition a reality.
Not only do the visitors travel north hoping to cement their claim on a top four spot, our showdown under the Etihad lights acts as a precursor to this season's Champions League final.
And ahead of our Premier League encounter, Guardiola doffed his cap to both the job that Tuchel has done in his managerial career so far and the way his Chelsea team currently operate under his guidance.
"I have a lot of respect for Thomas," he revealed in his pre-match press conference.
"He has been in Mainz, Dortmund, PSG and now here, in every place he has been he has always done really well and the teams are always a joy to watch.
"I have not been working with him so I don’t know [what he does], but he has always done really well.
"I am not surprised and huge compliments for what they have done so far."
Hear Pep's pre-match thoughts in full via the video above...
CITY v Chelsea
We will have full coverage of Saturday's game right here on ManCity.com
Live text updates in our Matchday Centre will begin at 15:30.
And our We're Not Really Here studio show starts at 16:25. Joleon Lescott and Nedum Onuoha are our guests for this one.
Short highlights are available from 21:15 - and CITY+ subscribers can watch a full 90-minute replay from midnight.